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Tmem88a Mediates GATA-dependent Specification of Cardiomyocyte Progenitors by Restricting Canonical WNT Signaling

ABSTRACT: We sequenced mRNA from zebrafish wild-type embryos, gata5 morphants, gata6 morphants, and gata5/6 morphants at bud and 6-somite developmental stages to identify genes co-operatively regulated by gata5 and gata6 during cardiomyocyte progenitor specification. Samples were collected in duplicate, with 40 embryos per sample. Single 36-base pair reads were sequenced on the Illumina Genome Analyzer IIx

ORGANISM(S): Danio rerio

SUBMITTER: Todd Evans

PROVIDER: E-GEOD-44026 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Tmem88a mediates GATA-dependent specification of cardiomyocyte progenitors by restricting WNT signaling.

Novikov Natasha N Evans Todd T

Development (Cambridge, England) 20130731 18

Biphasic control of WNT signaling is essential during cardiogenesis, but how the pathway switches from promoting cardiac mesoderm to restricting cardiomyocyte progenitor fate is unknown. We identified genes expressed in lateral mesoderm that are dysregulated in zebrafish when both gata5 and gata6 are depleted, causing a block to cardiomyocyte specification. This screen identified tmem88a, which is expressed in the early cardiac progenitor field and was previously implicated in WNT modulation by ...[more]

PMID: 23903195

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