Unknown,Transcriptomics,Genomics,Proteomics

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KRAB/KAP1-microRNA cascade regulates erythropoiesis through the stage-specific control of mitophagy [array]


ABSTRACT: A multilayered transcription regulatory system is unveiled, where protein- and RNA-based repressors are super-imposed in combinatorial fashion to govern the timely triggering of an essential step of erythropoiesis Analyses of transcriptional profiles and chromatin state in KAP1 WT and KO cells

ORGANISM(S): Mus musculus

SUBMITTER: Adamandia Kapopoulou 

PROVIDER: E-GEOD-44063 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A KRAB/KAP1-miRNA cascade regulates erythropoiesis through stage-specific control of mitophagy.

Barde Isabelle I   Rauwel Benjamin B   Marin-Florez Ray Marcel RM   Corsinotti Andrea A   Laurenti Elisa E   Verp Sonia S   Offner Sandra S   Marquis Julien J   Kapopoulou Adamandia A   Vanicek Jiri J   Trono Didier D  

Science (New York, N.Y.) 20130314 6130


During hematopoiesis, lineage- and stage-specific transcription factors work in concert with chromatin modifiers to direct the differentiation of all blood cells. We explored the role of KRAB-containing zinc finger proteins (KRAB-ZFPs) and their cofactor KAP1 in this process. In mice, hematopoietic-restricted deletion of Kap1 resulted in severe hypoproliferative anemia. Kap1-deleted erythroblasts failed to induce mitophagy-associated genes and retained mitochondria. This was due to persistent ex  ...[more]

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