Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: tomomi ide
PROVIDER: E-GEOD-44108 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Onitsuka Ken K Ide Tomomi T Arai Shinobu S Hata Yuko Y Murayama Yoshinori Y Hosokawa Kazuya K Sakamoto Takafumi T Tobushi Tomoyuki T Sakamoto Kazuo K Fujino Takeo T Sunagawa Kenji K
Journal of molecular and cellular cardiology 20130901
The heart has remarkable capacity to adapt to mechanical load and to dramatically change its phenotype. The mechanism underlying such diverse phenotypic adaptations remains unknown. Since systolic overload induces wall thickening, while diastolic overload induces chamber enlargement, we hypothesized that cardiac phase-sensitive mechanisms govern the adaptation. We inserted a balloon into the left ventricle (LV) of a Langendorff perfused rat heart, and controlled LV volume (LVV) using a high perf ...[more]