Sodium arsenite induced gene expression changes in A549 human epithelial lung carcinoma cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Simone van Breda
PROVIDER: E-GEOD-44169 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Epigenetic mechanisms underlying arsenic-associated lung carcinogenesis.
van Breda Simone G J SG Claessen Sandra M H SM Lo Ken K van Herwijnen Marcel M Brauers Karen J J KJ Lisanti Sofia S Theunissen Daniël H J DH Jennen Danyel G J DG Gaj Stan S de Kok Theo M C M TM Kleinjans Jos C S JC
Archives of toxicology 20140909 11
Arsenic is an established human carcinogen, but the mechanisms through which it contributes to for instance lung cancer development are still unclear. As arsenic is methylated during its metabolism, it may interfere with the DNA methylation process, and is therefore considered to be an epigenetic carcinogen. In the present study, we hypothesize that arsenic is able to induce DNA methylation changes, which lead to changes in specific gene expression, in pathways associated with lung cancer promot ...[more]
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