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Transcription profiling of subcutaneous fat from mice supplemented with niacin bound chromium or water for ten weeks to study effect of niacin bound chromium on genetic profile in diabetic mice.

ABSTRACT: To study effect of niacin bound chromium in changing genetic profile of subcutaneous fat from diabetic mice Experiment Overall Design: Two groups (n=4 each group) of mice were supplemented (oral gavage) with: i) niacin bound chromium (10 mg/kg body wt) in water for 10 wks (5d/wk) or ii) matching volume of water. After 10 wks of supplementation the subcutaneous fat was harvested and gene expression profile was studied using Affymetrix mouse genome 430 v 2.0 chips.

ORGANISM(S): Mus musculus

SUBMITTER: Sashwati Roy

PROVIDER: E-GEOD-4420 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcriptome of the subcutaneous adipose tissue in response to oral supplementation of type 2 Leprdb obese diabetic mice with niacin-bound chromium.

Rink Cameron C Roy Sashwati S Khanna Savita S Rink Trenton T Bagchi Debasis D Sen Chandan K CK

Physiological genomics 20060829 3

The effects of oral niacin-bound chromium (NBC) supplementation on the subcutaneous fat tissue of type 2 Lepr(db) obese diabetic mice were examined using high-density comprehensive mouse genome (45,101 probe sets) expression arrays. The influence of such supplementation on the plasma cardiovascular risk factors of these mice was also investigated. Supplementation of NBC had no significant effect on age-dependent weight gain in the Lepr(db) obese diabetic mice. However, NBC lowered total choleste ...[more]

PMID: 16940432

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