Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Joshua Bleharski
PROVIDER: E-GEOD-443 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Bleharski Joshua R JR Li Huiying H Meinken Christoph C Graeber Thomas G TG Ochoa Maria-Teresa MT Yamamura Masahiro M Burdick Anne A Sarno Euzenir N EN Wagner Manfred M Röllinghoff Martin M Rea Thomas H TH Colonna Marco M Stenger Steffen S Bloom Barry R BR Eisenberg David D Modlin Robert L RL
Science (New York, N.Y.) 20030901 5639
Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mech ...[more]