Unknown,Transcriptomics,Genomics,Proteomics

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Sox11 loss-of-function mutant cortex at E17.5


ABSTRACT: Expression profiling of cortex from embryonic day (E) 17.5 telencephalon of Sox11(+/+) and Sox11(-/-) mouse embryos. Sox11 is implicated in regulating proliferation, neuronal migration and differentiation. We used microarray to identify genes that were differentially expressed in the cortex in the wild type and Sox11 knockout embryos at E17.5. To uncover the molecular mechanisms undelying the function of Sox11 in cortical development, we conducted microarray analysis of E17.5 cortices from wild type and Sox11(-/-) mice. Total RNA was isolated from the cortex of one wild type embryo and one Sox11(-/-) littermate at E17.5. cRNA probe synthesis, hybridization, scanning, and data collection were performed following the manufacturer's instruction.

ORGANISM(S): Mus musculus

SUBMITTER: Lei Lei 

PROVIDER: E-GEOD-44308 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Transcription factor Sox11 is essential for both embryonic and adult neurogenesis.

Wang Yong Y   Lin Lu L   Lai Helen H   Parada Luis F LF   Lei Lei L  

Developmental dynamics : an official publication of the American Association of Anatomists 20130428 6


<h4>Background</h4>Neurogenesis requires neural progenitor cell (NPC) proliferation, neuronal migration, and differentiation. During embryonic development, neurons are generated in specific areas of the developing neuroepithelium and migrate to their appropriate positions. In the adult brain, neurogenesis continues in the subgranular zone (SGZ) of the hippocampal dentate gyrus and the subventricular zone (SVZ) of the lateral ventricle. Although neurogenesis is fundamental to brain development an  ...[more]

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