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Expression data from wild-type and HMGN1 knockout mice injected with N-nitrosodiethylamine

ABSTRACT: HMGN1 contributes to the shortened latency of liver tumorigenesis by changing a chromatin structure and expression of relevant genes To assess the molecular mechanisms underlying accelerated tumor development in Hmgn1-/- mice, we performed the gene expression profiling of liver cells at early stages Expression profiles has been compared between Hmgn1+/+ and Hmgn1-/- mice livers at 4 weeks after birth and at 12 weeks after DEN or saline (control) injection at 4 weeks

ORGANISM(S): Mus musculus

SUBMITTER: Yuri Postnikov

PROVIDER: E-GEOD-44356 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Loss of the nucleosome-binding protein HMGN1 affects the rate of N-nitrosodiethylamine-induced hepatocarcinogenesis in mice.

Postnikov Yuri V YV Furusawa Takashi T Haines Diana C DC Factor Valentina M VM Bustin Michael M

Molecular cancer research : MCR 20131202 1

<h4>Unlabelled</h4>We report that HMGN1, a nucleosome-binding protein that affects chromatin structure and function, affects the growth of N-nitrosodiethylamine (DEN)-induced liver tumors. Following a single DEN injection at 2 weeks of age, Hmgn1(tm1/tm1) mice, lacking the nucleosome-binding domain of HMGN1, had earlier signs of liver tumorigenesis than their Hmgn1(+/+) littermates. Detailed gene expression profiling revealed significant differences between DEN-injected and control saline-inject ...[more]

PMID: 24296759

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