Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human newly diagnised multiple myeloma patients prior to treatment

ABSTRACT: Samples in this series are pre-treatment bone marrow aspirates from multiple myeloma patients Experiment Overall Design: Samples in this series are: CD-138-selected plasma cells from bone marrow of newly diagnosed multiple myeloma patients susequently treated with Total Therapy

ORGANISM(S): Homo sapiens

SUBMITTER: Shaughnessy Jr John 

PROVIDER: E-GEOD-4452 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

To identify genetic events underlying the genesis and progression of multiple myeloma (MM), we conducted a high-resolution analysis of recurrent copy number alterations (CNAs) and expression profiles in a collection of MM cell lines and outcome-annotated clinical specimens. Attesting to the molecular heterogeneity of MM, unsupervised classification using nonnegative matrix factorization (NMF) designed for array comparative genomic hybridization (aCGH) analysis uncovered distinct genomic subtypes  ...[more]

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