Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Annaick Carles
PROVIDER: E-GEOD-44543 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
del Valle Ignacio I Rudloff Stefan S Carles Annaick A Li Yong Y Liszewska Ewa E Vogt Riana R Kemler Rolf R
Development (Cambridge, England) 20130313 8
The leukemia inhibitory factor (Lif) signaling pathway is a crucial determinant for mouse embryonic stem (mES) cell self-renewal and pluripotency. One of the hallmarks of mES cells, their compact growth morphology, results from tight cell adhesion mediated through E-cadherin, β-catenin (Ctnnb1) and α-catenin with the actin cytoskeleton. β-catenin is also involved in canonical Wnt signaling, which has also been suggested to control mES cell stemness. Here, we analyze Ctnnb1(-/-) mES cells in whic ...[more]