Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from mouse embryonic stem cells


ABSTRACT: Analysis of the transcriptome of ß-catenin flox/- mES cells in comparison with ß-catenin null mES cells or ß-catenin null mES cells stably transfected with an E-cadherin-?-catenin fusion protein. Expression assay was performed using the Affymetrix GeneChip Mouse Gene 1.0 ST array. The experiment includes ß-catenin flox/-, ß-catenin null and ß-catenin null E? mouse embryonic stem cells with three biological replicates for each sample.

ORGANISM(S): Mus musculus

SUBMITTER: Annaick Carles 

PROVIDER: E-GEOD-44543 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

E-cadherin is required for the proper activation of the Lifr/Gp130 signaling pathway in mouse embryonic stem cells.

del Valle Ignacio I   Rudloff Stefan S   Carles Annaick A   Li Yong Y   Liszewska Ewa E   Vogt Riana R   Kemler Rolf R  

Development (Cambridge, England) 20130313 8


The leukemia inhibitory factor (Lif) signaling pathway is a crucial determinant for mouse embryonic stem (mES) cell self-renewal and pluripotency. One of the hallmarks of mES cells, their compact growth morphology, results from tight cell adhesion mediated through E-cadherin, β-catenin (Ctnnb1) and α-catenin with the actin cytoskeleton. β-catenin is also involved in canonical Wnt signaling, which has also been suggested to control mES cell stemness. Here, we analyze Ctnnb1(-/-) mES cells in whic  ...[more]

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