Androgen receptor coregulators
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Paul-Martin Holterhus
PROVIDER: E-GEOD-4456 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Cell-line and tissue-specific signatures of androgen receptor-coregulator transcription.
Bebermeier Jan-Hendrik JH Brooks James D JD DePrimo Samuel E SE Werner Ralf R Deppe Uta U Demeter Janos J Hiort Olaf O Holterhus Paul-Martin PM
Journal of molecular medicine (Berlin, Germany) 20060824 11
Normal genital skin fibroblasts (GSF) and the human prostate carcinoma cell line LNCaP have been used widely as cell culture models of genital origin to study androgen receptor (AR) signaling. We demonstrate that LNCaP shows a reproducible response to androgens as assessed using cDNA-microarrays representing approximately 32,000 unique human genes, whereas several independent GSF strains are virtually unresponsive. We show that LNCaP cells express markedly higher AR protein levels likely contrib ...[more]
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