Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Susanne Walz
PROVIDER: E-GEOD-44672 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Walz Susanne S Lorenzin Francesca F Morton Jennifer J Wiese Katrin E KE von Eyss Björn B Herold Steffi S Rycak Lukas L Dumay-Odelot Hélène H Karim Saadia S Bartkuhn Marek M Roels Frederik F Wüstefeld Torsten T Fischer Matthias M Teichmann Martin M Zender Lars L Wei Chia-Lin CL Sansom Owen O Wolf Elmar E Eilers Martin M
Nature 20140709 7510
In mammalian cells, the MYC oncoprotein binds to thousands of promoters. During mitogenic stimulation of primary lymphocytes, MYC promotes an increase in the expression of virtually all genes. In contrast, MYC-driven tumour cells differ from normal cells in the expression of specific sets of up- and downregulated genes that have considerable prognostic value. To understand this discrepancy, we studied the consequences of inducible expression and depletion of MYC in human cells and murine tumour ...[more]