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Gene expression in post cardiac surgery acute kidney injury

ABSTRACT: To determine the changes in intra-renal gene expression in a novel large animal model of post Cardiopulmonary Bypass (CPB) acute kidney injury, we collected renal medulla samples obtained 24hours post intervention. The transcriptional profile of the mRNA in these samples was measured with gene array technology. Pigs were subjected to 2.5 hours of general anaesthesia or 2.5 hours of CPB under general anaesthesia. Renal medulla samples were collected 24 hours post intervention.

ORGANISM(S): Sus scrofa

SUBMITTER: Mohamed Ghorbel

PROVIDER: E-GEOD-44782 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Changes in renal medulla gene expression in a pre-clinical model of post cardiopulmonary bypass acute kidney injury.

Ghorbel Mohamed T MT Patel Nishith N NN Sheikh Maimuna M Angelini Gianni D GD Caputo Massimo M Murphy Gavin J GJ

BMC genomics 20141021

<h4>Background</h4>Acute kidney injury (AKI) is a common and serious complication of cardiac surgery using cardiopulmonary bypass (CPB). The pathogenesis is poorly understood and the study of AKI in rodent models has not led to improvements in clinical outcomes. We sought to determine the changes in renal medullary gene expression in a novel and clinically relevant porcine model of CPB-induced AKI.<h4>Results</h4>Adult pigs (n = 12 per group) were randomised to undergo sham procedure, or 2.5 hou ...[more]

PMID: 25331815

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