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Defining a Th9 transcriptome

ABSTRACT: Microarray analyses were performed to compare gene expression in cultured mouse Th9, Th2 and Treg cells and resting versus activated Th9 cells. Three replicates were analyzed for each culture condition; Th9 unstim, Th2 unstim, Treg unstim, Th9 stim

ORGANISM(S): Mus musculus

SUBMITTER: Mark Kaplan

PROVIDER: E-GEOD-44937 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Th9 cell development requires a BATF-regulated transcriptional network.

Jabeen Rukhsana R Goswami Ritobrata R Awe Olufolakemi O Kulkarni Aishwarya A Nguyen Evelyn T ET Attenasio Andrea A Walsh Daniel D Olson Matthew R MR Kim Myung H MH Tepper Robert S RS Sun Jie J Kim Chang H CH Taparowsky Elizabeth J EJ Zhou Baohua B Kaplan Mark H MH

The Journal of clinical investigation 20131101 11

T helper 9 (Th9) cells are specialized for the production of IL-9, promote allergic inflammation in mice, and are associated with allergic disease in humans. It has not been determined whether Th9 cells express a characteristic transcriptional signature. In this study, we performed microarray analysis to identify genes enriched in Th9 cells compared with other Th subsets. This analysis defined a transcriptional regulatory network required for the expression of a subset of Th9-enriched genes. The ...[more]

PMID: 24216482

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