Unknown,Transcriptomics,Genomics,Proteomics

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Gene Expression in Bone-marrow derived Dendritic Cells stimulated with H. pylori lysate vs. E. coli lysate


ABSTRACT: Gene Expression changes in BMDCs stimulated with H. pylori vs. E. coli. The hypothesis tested was that the gene expression profile in BMDCs stimulated with H. pylori lysate will be less inflammatory than BMDCs stimulated with E. coli. BMDCs were generated from bone marrow of wild type female C57BL/6 mice using 100ng/mL Flt3L. DCs were harvested at day 8 and stimulated with either media alone, H. pylori antigen lysate or E. coli lysate. At 24 hours, the cells were harvested and RNA was isolated for microarray analysis.

ORGANISM(S): Mus musculus

SUBMITTER: Jessica Shiu 

PROVIDER: E-GEOD-44954 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

IRAK-M expression limits dendritic cell activation and proinflammatory cytokine production in response to Helicobacter pylori.

Shiu Jessica J   Czinn Steven J SJ   Kobayashi Koichi S KS   Sun Yezhou Y   Blanchard Thomas G TG  

PloS one 20130611 6


Helicobacter pylori (H. pylori) infects the gastric mucosa and persists for the life of the host. Bacterial persistence may be due to the induction of regulatory T cells (Tregs) whichmay have protective effects against other diseases such as asthma. It has been shown that H. pylori modulates the T cell response through dendritic cell reprogramming but the molecular pathways involved are relatively unknown. The goal of this study was to identify critical elements of dendritic cell (DC) activation  ...[more]

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