Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Anuhar Chaturvedi
PROVIDER: E-GEOD-45019 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Chaturvedi Anuhar A Araujo Cruz Michelle Maria MM Jyotsana Nidhi N Sharma Amit A Yun Haiyang H Görlich Kerstin K Wichmann Martin M Schwarzer Adrian A Preller Matthias M Thol Felicitas F Meyer Johann J Haemmerle Reinhard R Struys Eduard A EA Jansen Erwin E EE Modlich Ute U Li Zhixiong Z Sly Laura M LM Geffers Robert R Lindner Robert R Manstein Dietmar J DJ Lehmann Ulrich U Krauter Jürgen J Ganser Arnold A Heuser Michael M
Blood 20130816 16
Mutations in the metabolic enzymes isocitrate dehydrogenase 1 (IDH1) and 2 (IDH2) are frequently found in glioma, acute myeloid leukemia (AML), melanoma, thyroid cancer, and chondrosarcoma patients. Mutant IDH produces 2-hydroxyglutarate (2HG), which induces histone- and DNA-hypermethylation through inhibition of epigenetic regulators. We investigated the role of mutant IDH1 using the mouse transplantation assay. Mutant IDH1 alone did not transform hematopoietic cells during 5 months of observat ...[more]