Transcription profiling of rat testes following exposure to mono-(2-ethylhexyl) phthalate
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Kamin Johnson
PROVIDER: E-GEOD-4514 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Testicular gene expression profiling following prepubertal rat mono-(2-ethylhexyl) phthalate exposure suggests a common initial genetic response at fetal and prepubertal ages.
Lahousse Stephanie A SA Wallace Duncan G DG Liu Delong D Gaido Kevin W KW Johnson Kamin J KJ
Toxicological sciences : an official journal of the Society of Toxicology 20060629 2
Phthalate chemical plasticizers can damage the fetal and postnatal mammalian testis, but several aspects of the injury mechanism remain unknown. Using a genome-wide microarray, the profile of testicular gene expression changes was examined following exposure of postnatal day 28 rats to a single, high dose (1000 mg/kg) of mono-(2-ethylhexyl) phthalate (MEHP). By microarray analysis, approximately 1675 nonredundant genes exhibited significant expression changes; the vast majority were observed at ...[more]
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