Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Scott Diede
PROVIDER: E-GEOD-45240 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Diede Scott J SJ Yao Zizhen Z Keyes C Chip CC Tyler Ashlee E AE Dey Joyoti J Hackett Christopher S CS Elsaesser Katrina K Kemp Christopher J CJ Neiman Paul E PE Weiss William A WA Olson James M JM Tapscott Stephen J SJ
Epigenetics 20131009 12
Genetic and epigenetic alterations are essential for the initiation and progression of human cancer. We previously reported that primary human medulloblastomas showed extensive cancer-specific CpG island DNA hypermethylation in critical developmental pathways. To determine whether genetically engineered mouse models (GEMMs) of medulloblastoma have comparable epigenetic changes, we assessed genome-wide DNA methylation in three mouse models of medulloblastoma. In contrast to human samples, very fe ...[more]