Ontology highlight
ABSTRACT:
ORGANISM(S): Macaca mulatta
SUBMITTER: zs li
PROVIDER: E-GEOD-45244 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Li Zhongshan Z Bammann Hindrike H Li Mingshuang M Liang Hongyu H Yan Zheng Z Phoebe Chen Yi-Ping YP Zhao Min M Khaitovich Philipp P
RNA (New York, N.Y.) 20131023 12
Adenosine-to-inosine (A-to-I) substitutions are the most common type of RNA editing in mammals. A-to-I RNA editing is particularly widespread in the brain and is known to play important roles in neuronal functions. In this study we investigated RNA-editing changes during human brain development and maturation, as well as evolutionary conservation of RNA-editing patterns across primates. We used high-throughput transcriptome sequencing (RNA-seq) to quantify the RNA-editing levels and assess ontog ...[more]