Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of livers from wild type, Clock mutant and Cry deficient C57BL/6 mice to characterize CLOCK-regulated circadian output genes.

ABSTRACT: Molecular analysis of circadian rhythm in mice. Liver tissue of wildtype, Clock mutant and Cry deficient C57BL/6 8- to 10-week-old male mice examined.

ORGANISM(S): Mus musculus

SUBMITTER: Norio Ishida

PROVIDER: E-GEOD-454 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genes.

Oishi Katsutaka K Miyazaki Koyomi K Kadota Koji K Kikuno Reiko R Nagase Takahiro T Atsumi Gen-ichi G Ohkura Naoki N Azama Takashi T Mesaki Miho M Yukimasa Shima S Kobayashi Hisato H Iitaka Chisato C Umehara Takashi T Horikoshi Masami M Kudo Takashi T Shimizu Yoshihisa Y Yano Masahiko M Monden Morito M Machida Kazuhiko K Matsuda Juzo J Horie Shuichi S Todo Takeshi T Ishida Norio N

The Journal of biological chemistry 20030715 42

CLOCK is a positive component of a transcription/translation-based negative feedback loop of the central circadian oscillator in the suprachiasmatic nucleus in mammals. To examine CLOCK-regulated circadian transcription in peripheral tissues, we performed microarray analyses using liver RNA isolated from Clock mutant mice. We also compared expression profiles with those of Cryptochromes (Cry1 and Cry2) double knockout mice. We identified more than 100 genes that fluctuated from day to night and ...[more]

PMID: 12865428

Dataset Information

Transcription profiling of livers from wild type, Clock mutant and Cry deficient C57BL/6 mice to characterize CLOCK-regulated circadian output genes.

Publications

Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genes.

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