Transcription profiling of livers from wild type, Clock mutant and Cry deficient C57BL/6 mice to characterize CLOCK-regulated circadian output genes.
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Norio Ishida
PROVIDER: E-GEOD-454 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genes.
Oishi Katsutaka K Miyazaki Koyomi K Kadota Koji K Kikuno Reiko R Nagase Takahiro T Atsumi Gen-ichi G Ohkura Naoki N Azama Takashi T Mesaki Miho M Yukimasa Shima S Kobayashi Hisato H Iitaka Chisato C Umehara Takashi T Horikoshi Masami M Kudo Takashi T Shimizu Yoshihisa Y Yano Masahiko M Monden Morito M Machida Kazuhiko K Matsuda Juzo J Horie Shuichi S Todo Takeshi T Ishida Norio N
The Journal of biological chemistry 20030715 42
CLOCK is a positive component of a transcription/translation-based negative feedback loop of the central circadian oscillator in the suprachiasmatic nucleus in mammals. To examine CLOCK-regulated circadian transcription in peripheral tissues, we performed microarray analyses using liver RNA isolated from Clock mutant mice. We also compared expression profiles with those of Cryptochromes (Cry1 and Cry2) double knockout mice. We identified more than 100 genes that fluctuated from day to night and ...[more]
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