Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Seung-Tae Lee
PROVIDER: E-GEOD-45461 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Lee Seung-Tae ST Xiao Yuanyuan Y Muench Marcus O MO Xiao Jianqiao J Fomin Marina E ME Wiencke John K JK Zheng Shichun S Dou Xiaoqin X de Smith Adam A Chokkalingam Anand A Buffler Patricia P Ma Xiaomei X Wiemels Joseph L JL
Nucleic acids research 20121016 22
The epigenetic changes during B-cell development relevant to both normal function and hematologic malignancy are incompletely understood. We examined DNA methylation and RNA expression status during early B-cell development by sorting multiple replicates of four separate stages of pre-B cells derived from normal human fetal bone marrow and applied high-dimension DNA methylation scanning and expression arrays. Features of promoter and gene body DNA methylation were strongly correlated with RNA ex ...[more]