Unknown,Transcriptomics,Genomics,Proteomics

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A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network.


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Seung-Tae Lee 

PROVIDER: E-GEOD-45461 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A global DNA methylation and gene expression analysis of early human B-cell development reveals a demethylation signature and transcription factor network.

Lee Seung-Tae ST   Xiao Yuanyuan Y   Muench Marcus O MO   Xiao Jianqiao J   Fomin Marina E ME   Wiencke John K JK   Zheng Shichun S   Dou Xiaoqin X   de Smith Adam A   Chokkalingam Anand A   Buffler Patricia P   Ma Xiaomei X   Wiemels Joseph L JL  

Nucleic acids research 20121016 22


The epigenetic changes during B-cell development relevant to both normal function and hematologic malignancy are incompletely understood. We examined DNA methylation and RNA expression status during early B-cell development by sorting multiple replicates of four separate stages of pre-B cells derived from normal human fetal bone marrow and applied high-dimension DNA methylation scanning and expression arrays. Features of promoter and gene body DNA methylation were strongly correlated with RNA ex  ...[more]

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