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Comparison of gene expression of miltefosine responsive Vs miltefosine unresponsive Leishmania donovani promastigotes

ABSTRACT: The current study aims to study change in gene expression profile of miltefosine resistance L. donovani with respect to miltefosine responsive L. donovani. Agilent one-color experiment,Organism: Leishmania donovani, Microarray GeneExpression 8x15k designed by Genotypic Technology Private Limited. (AMADID: 035638)

ORGANISM(S): Leishmania donovani

SUBMITTER: Vikash Dubey

PROVIDER: E-GEOD-45496 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Miltefosine-unresponsive Leishmania donovani has a greater ability than miltefosine-responsive L. donovani to resist reactive oxygen species.

Das Mousumi M Saudagar Prakash P Sundar Shyam S Dubey Vikash K VK

The FEBS journal 20130823 19

Resistance of Leishmania parasites to miltefosine, which is only available oral drug, is a great concern. We have analyzed global gene expression profiles of miltefosine-unresponsive and miltefosine-responsive Leishmania donovani in order to understand the various metabolic processes involved in miltefosine drug resistance. The microarray data clearly indicated a role of oxidative metabolism in miltefosine resistance. Furthermore, fluorescence microscopy experiments suggested that miltefosine-un ...[more]

PMID: 23890327

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