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Human Alopecia Areata Skin Profiling

ABSTRACT: Our goal was to develop a transcriptomic description of affected alopecic scalp skin from patients with alopecia areata. 5 biological replicates of skin samples from 5 separate AA patients compared with 5 similar scalp samples from healthy control patients

ORGANISM(S): Homo sapiens

SUBMITTER: Ali Jabbari

PROVIDER: E-GEOD-45512 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition.

Xing Luzhou L Dai Zhenpeng Z Jabbari Ali A Cerise Jane E JE Higgins Claire A CA Gong Weijuan W de Jong Annemieke A Harel Sivan S DeStefano Gina M GM Rothman Lisa L Singh Pallavi P Petukhova Lynn L Mackay-Wiggan Julian J Christiano Angela M AM Clynes Raphael R

Nature medicine 20140817 9

Alopecia areata (AA) is a common autoimmune disease resulting from damage of the hair follicle by T cells. The immune pathways required for autoreactive T cell activation in AA are not defined limiting clinical development of rational targeted therapies. Genome-wide association studies (GWAS) implicated ligands for the NKG2D receptor (product of the KLRK1 gene) in disease pathogenesis. Here, we show that cytotoxic CD8(+)NKG2D(+) T cells are both necessary and sufficient for the induction of AA i ...[more]

PMID: 25129481

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