Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Stephen Welle
PROVIDER: E-GEOD-45734 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Scientific reports 20130101
To identify sources of inter-subject variation in vaccine responses, we performed high-frequency sampling of human peripheral blood cells post-vaccination, followed by a novel systems biology analysis. Functional principal component analysis was used to examine time varying B cell vaccine responses. In subjects vaccinated within the previous three years, 90% of transcriptome variation was explained by a single subject-specific mathematical pattern. Within individual vaccine response patterns, a ...[more]