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Gene expression in degenerated rat supraspinatus tendon

ABSTRACT: Microarray of exercised (degenerated) rat supraspinatus versus non-exercised (normal) rats were subjected to exercise that consisted of running on a 10Ë decline at 17m/min for 1 hour per day, 5 days per week. This regimen equates to approximately 7500 strides per day. After four weeks of running, rats were sacrificed by CO2 inhalation and both supraspinatus tendons were collected. 12 non-exercised rats were used as controls.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Tim Molloy

PROVIDER: E-GEOD-4575 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Microarray analysis of the tendinopathic rat supraspinatus tendon: glutamate signaling and its potential role in tendon degeneration.

Molloy T J TJ Kemp M W MW Wang Y Y Murrell G A C GA

Journal of applied physiology (Bethesda, Md. : 1985) 20060803 6

Degenerative tendon injury or "tendinopathy" is one of the most common disorders of the musculoskeletal system. We used a rat model (Soslowsky LJ, Thomopoulos S, Tun S, Flanagan CL, Keefer CC, Mastaw J, and Carpenter JE. J Shoulder Elbow Surg 9: 79-84, 2000) to identify novel gene expression in the exercised-induced degenerated supraspinatus tendon by microarray and real-time PCR analyses. We identified several novel groups of differentially expressed genes, including those involved in apoptosis ...[more]

PMID: 16888051

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