Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Jessica Von Stetina
PROVIDER: E-GEOD-45787 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Sher Noa N Von Stetina Jessica R JR Bell George W GW Matsuura Shinobu S Ravid Katya K Orr-Weaver Terry L TL
Proceedings of the National Academy of Sciences of the United States of America 20130423 23
Throughout the plant and animal kingdoms specific cell types become polyploid, increasing their DNA content to attain a large cell size. In mammals, megakaryocytes (MKs) become polyploid before fragmenting into platelets. The mammalian trophoblast giant cells (TGCs) exploit their size to form a barrier between the maternal and embryonic tissues. The mechanism of polyploidization has been investigated extensively in Drosophila, in which a modified cell cycle--the endocycle, consisting solely of a ...[more]