Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Esther Rheinbay
PROVIDER: E-GEOD-46015 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Rheinbay Esther E Suvà Mario L ML Gillespie Shawn M SM Wakimoto Hiroaki H Patel Anoop P AP Shahid Mohammad M Oksuz Ozgur O Rabkin Samuel D SD Martuza Robert L RL Rivera Miguel N MN Louis David N DN Kasif Simon S Chi Andrew S AS Bernstein Bradley E BE
Cell reports 20130523 5
Glioblastoma (GBM) is thought to be driven by a subpopulation of cancer stem cells (CSCs) that self-renew and recapitulate tumor heterogeneity yet remain poorly understood. Here, we present a comparative analysis of chromatin state in GBM CSCs that reveals widespread activation of genes normally held in check by Polycomb repressors. These activated targets include a large set of developmental transcription factors (TFs) whose coordinated activation is unique to the CSCs. We demonstrate that a cr ...[more]