Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Mark Katzenellenbogen
PROVIDER: E-GEOD-4612 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Katzenellenbogen Mark M Pappo Orit O Barash Hila H Klopstock Naama N Mizrahi Lina L Olam Devorah D Jacob-Hirsch Jasmine J Amariglio Ninette N Rechavi Gidi G Mitchell Leslie Ann LA Kohen Ron R Domany Eytan E Galun Eithan E Goldenberg Daniel D
Cancer research 20060401 8
Molecular events preceding the development of hepatocellular carcinoma were studied in the Mdr2-knockout (Mdr2-KO) mice. These mice lack the liver-specific P-glycoprotein responsible for phosphatidylcholine transport across the canalicular membrane. Portal inflammation ensues at an early age followed by hepatocellular carcinoma development after the age of 1 year. Liver tissue samples of Mdr2-KO mice in the early and late precancerous stages of liver disease were subjected to histologic, biochem ...[more]