Transcription profiling of mouse uteri to evaluate the mechanism and physiological effects of estren
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ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: NIEHS Microarray Group
PROVIDER: E-GEOD-4615 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Estren behaves as a weak estrogen rather than a nongenomic selective activator in the mouse uterus.
Hewitt Sylvia C SC Collins Jennifer J Grissom Sherry S Hamilton Katherine K Korach Kenneth S KS
Endocrinology 20060209 5
A proposed membrane-mediated mechanism of rapid nongenomic response to estrogen has been the intense focus of recent research. Estren, a synthetic steroid, is reported to act selectively through a rapid membrane-mediated pathway, rather than through the classical nuclear estrogen receptor (ER)-mediated pathway, to maintain bone density in ovariectomized mice without uterotropic effects. To evaluate the mechanism and physiological effects of estren, we studied responses in adult ovariectomized mi ...[more]
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