Deep RNA Sequencing Reveals Dynamic Regulation of Myocardial Noncoding RNA in Failing Human Heart and Remodeling with Mechanical Circulatory Support
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Kai-Chien Yang
PROVIDER: E-GEOD-46224 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Deep RNA sequencing reveals dynamic regulation of myocardial noncoding RNAs in failing human heart and remodeling with mechanical circulatory support.
Yang Kai-Chien KC Yamada Kathryn A KA Patel Akshar Y AY Topkara Veli K VK George Isaac I Cheema Faisal H FH Ewald Gregory A GA Mann Douglas L DL Nerbonne Jeanne M JM
Circulation 20140115 9
<h4>Background</h4>Microarrays have been used extensively to profile transcriptome remodeling in failing human heart, although the genomic coverage provided is limited and fails to provide a detailed picture of the myocardial transcriptome landscape. Here, we describe sequencing-based transcriptome profiling, providing comprehensive analysis of myocardial mRNA, microRNA (miRNA), and long noncoding RNA (lncRNA) expression in failing human heart before and after mechanical support with a left vent ...[more]
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