CD4+ Tcell : control vs cocaine treated
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Chandravanu Dash
PROVIDER: E-GEOD-46398 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Cocaine enhances HIV-1 replication in CD4+ T cells by down-regulating MiR-125b.
Mantri Chinmay K CK Pandhare Dash Jui J Mantri Jyoti Velamarti JV Dash Chandravanu C V CC
PloS one 20121212 12
The main objective of this study was to examine effects of cocaine on HIV-1 replication in primary CD4+ T cells. Cocaine a commonly used drug among HIV-1 positive individuals serves as a cofactor for HIV-1 infection and progression to acquired immunodeficiency syndrome (AIDS). Accumulating evidence suggest that cocaine increases HIV-1 replication in cell cultures, peripheral blood mononuclear cells (PBMCs) and animal models. Intriguingly, there are no studies on cocaine-induced alterations in HI ...[more]
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