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Expression data from mouse cerebral cortex

ABSTRACT: Differential gene expression of cerebral cortex might be responsible for distinct neurovascular developments between different mouse strains We used Affymetrix microarray to explore the global gene expression patterns of mouse cerebral cortex of different mouse strains at two developmental stages Cerebral cortex from two mouse strains [C57BL/6J(B6) and C3H/J (C3H)] at post-natal day 1 (p1) and post-natal 11 weeks (11 wk) were harvested for microarray experiments

ORGANISM(S): Mus musculus

SUBMITTER: Douglas Marchuk

PROVIDER: E-GEOD-46443 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A novel genetic locus modulates infarct volume independently of the extent of collateral circulation.

Chu Pei-Lun PL Keum Sehoon S Marchuk Douglas A DA

Physiological genomics 20130625 17

In the mouse model of permanent, middle cerebral artery occlusion, infarct volume varies widely across inbred strains but generally is inversely correlated with collateral vessel number. However, we also observed certain mouse strains that share similar collateral vessel anatomy but exhibit significantly different infarct volume. To identify genetic factors determining infarct volume in a collateral vessel-independent manner, we performed quantitative trait locus analysis on a F2 cross between C ...[more]

PMID: 23800850

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