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Transcription profiling of rat treated with streptozotocin or buffer alone at age of 8 weeks, diaphragm muscle

ABSTRACT: 8 week old rats injected with streptozotocin or buffer alone at age of 8 weeks, diaphragm muscle obtained at age of 12 weeks (thus animals were diabetic for 4 weeks) Experiment Overall Design: Three control rats (normal diaphragm #1, 2, 3) Experiment Overall Design: Three diabetic rats (diabetic diaphragm #1, 2, 3)

ORGANISM(S): Rattus norvegicus

SUBMITTER: Erik -- van Lunteren

PROVIDER: E-GEOD-4653 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression profiling in the type 1 diabetes rat diaphragm.

van Lunteren Erik E Moyer Michelle M

PloS one 20091113 11

<h4>Background</h4>Respiratory muscle contractile performance is impaired by diabetes, mechanisms of which included altered carbohydrate and lipid metabolism, oxidative stress and changes in membrane electrophysiology. The present study examined to what extent these cellular perturbations involve changes in gene expression.<h4>Methodology/principal findings</h4>Diaphragm muscle from streptozotocin-diabetic rats was analyzed with Affymetrix gene expression arrays. Diaphragm from diabetic rats had ...[more]

PMID: 19915678

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