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Identification of differentially expressed transcripts and pathways one week and six months following implant of left ventricular devices

ABSTRACT: A specific set of genes involved in regulating cellular immune response, antigen presentation, and T cell activation and survival were down-regulated 7 days after LVAD placement. 6 months following LVAD placement, the expression levels of these genes were significantly increased; yet importantly, remained significantly lower than age and sex-matched samples from healthy controls. Examination of the effect of LVAD implant on peripheral blood transcriptome. Blood was drawn before LVAD placement, 7 days post implant, and 180 days post implant. RNA sequencing was performaed on all samples.

ORGANISM(S): Homo sapiens

SUBMITTER: Rod Staggs

PROVIDER: E-GEOD-46665 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification of differentially expressed transcripts and pathways in blood one week and six months following implant of left ventricular assist devices.

Mitchell Adam A Guan Weihua W Staggs Rodney R Hamel Aimee A Hozayen Sameh S Adhikari Neeta N Grindle Suzanne S Desir Snider S John Ranjit R Hall Jennifer L JL Eckman Peter P

PloS one 20131021 10

<h4>Introduction</h4>Continuous-flow left ventricular assist devices (LVADs) are an established therapy for patients with end-stage heart failure. The short- and long-term impact of these devices on peripheral blood gene expression has not been characterized, and may provide insight into the molecular pathways mediated in response to left ventricular remodeling and an improvement in overall systemic circulation. We performed RNA sequencing to identify genes and pathways influenced by these devic ...[more]

PMID: 24205042

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Identification of differentially expressed transcripts and pathways one week and six months following implant of left ventricular devices

Project description:A specific set of genes involved in regulating cellular immune response, antigen presentation, and T cell activation and survival were down-regulated 7 days after LVAD placement. 6 months following LVAD placement, the expression levels of these genes were significantly increased; yet importantly, remained significantly lower than age and sex-matched samples from healthy controls.

2013-05-06 | GSE46665 | GEO

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RNA-seq of human patient-derived xenograft pancreatic cancer Panc185 sphere-derived cells with the ISG15 gene edited using CRISPR-CAS9 against control spheres.

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