Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse white adipose tissue from mice fed trans-10, cis-12 conjugated linoleic acid to determine the processes involved in the generated inflammation and de-lipidation of the adipose tissue


ABSTRACT: The white adipose tissue (WAT) rapidly loses mass when mice are fed a diet containing trans-10, cis-12 conjugated linoleic acid (t10c12 CLA). A microarray analysis of WAT due to CLA feeding was performed to better define the processes and genes involved.

ORGANISM(S): Mus musculus

SUBMITTER: Chris LaRosa 

PROVIDER: E-GEOD-4671 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Trans-10, cis-12 conjugated linoleic acid causes inflammation and delipidation of white adipose tissue in mice: a microarray and histological analysis.

LaRosa P Christopher PC   Miner Jess J   Xia Yuannan Y   Zhou You Y   Kachman Steve S   Fromm Michael E ME  

Physiological genomics 20060725 3


A combined histological and microarray analysis of the white adipose tissue (WAT) of mice fed trans-10, cis-12 conjugated linoleic acid (t10c12 CLA) was performed to better define functional responses. Mice fed t10c12 CLA for 14 days lost 85% of WAT mass, 95% of adipocyte lipid droplet volume, and 15 or 47% of the number of adipocytes and total cells, respectively. Microarray profiling of replicated pools (n = 2 per day x diet) of control and treated mice (n = 140) at seven time points after 1-1  ...[more]

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