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Transcriptome based identification of mouse cumulus cell markers that predict the developmental competence of their enclosed antral oocytes


ABSTRACT: The cumulus cells (CCs) that envelope antral and ovulated oocytes have been regarded as putative source of non-invasive markers of the oocyte developmental competence and a number of studies have observed a correlation between CCs gene expression, embryo quality and final pregnancy outcome. With the aim of identifying marker transcripts, we isolated CCs from antral mouse oocytes of known developmental incompetence (NSN-CCs) or competence (SN-CCs) and compared their transcriptomes. Total RNA was isolated from cumulus cells derived from oocytes with a SN or NSN chromatin organization.

ORGANISM(S): Mus musculus

SUBMITTER: Alessandro Prigione 

PROVIDER: E-GEOD-46906 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcriptome based identification of mouse cumulus cell markers that predict the developmental competence of their enclosed antral oocytes.

Vigone Giulia G   Merico Valeria V   Prigione Alessandro A   Mulas Francesca F   Sacchi Lucia L   Gabetta Matteo M   Bellazzi Riccardo R   Redi Carlo Alberto CA   Mazzini Giuliano G   Adjaye James J   Garagna Silvia S   Zuccotti Maurizio M  

BMC genomics 20130607


<h4>Background</h4>The cumulus cells (CCs) enveloping antral and ovulated oocytes have been regarded as putative source of non-invasive markers of the oocyte developmental competence. A number of studies have indeed observed a correlation between CCs gene expression, embryo quality, and final pregnancy outcome. Here, we isolated CCs from antral mouse oocytes of known developmental incompetence (NSN-CCs) or competence (SN-CCs) and compared their transcriptomes with the aim of identifying distinct  ...[more]

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