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Differences in gene expression and cytokines levels between newly diagnosed and chronic pediatric immune thrombocytopenia (ITP)


ABSTRACT: Immune thrombocytopenia (ITP) is an autoimmune disease where platelets are destroyed prematurely. In the majority of children the disease resolves but in some it becomes chronic. To investigate whether the two forms of the disease are similar or separate entities we performed DNA microarray analysis of T-cells from newly diagnosed children and children with chronic ITP. We found complete separation of the expression files between the two forms of the disease. Furthermore, the gene expression of several cytokines differed between the two forms of the disease. This was also reflected in plasma with increased levels of IL-16 and TWEAK and lower levels of IL-4 in newly diagnosed compared with chronic ITP. Thus, our data indicate that the two forms of the disease may be separate entities. Microarray expression analysis of mRNA in peripheral blood T-cell of Newly diagnosed ITP vs Chronic ITP

ORGANISM(S): Homo sapiens

SUBMITTER: Intawat Nookaew 

PROVIDER: E-GEOD-46922 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Differences in gene expression and cytokine levels between newly diagnosed and chronic pediatric ITP.

Jernås Margareta M   Hou Yu Y   Strömberg Célind Frida F   Shao Linlin L   Nookaew Intawat I   Wang Qian Q   Ju Xiuli X   Mellgren Karin K   Wadenvik Hans H   Hou Ming M   Olsson Bob B  

Blood 20130718 10


Immune thrombocytopenia (ITP) is an autoimmune disease where platelets are destroyed prematurely. In the majority of children the disease resolves, but in some it becomes chronic. To investigate whether these 2 phases of the disease are molecularly similar or separate entities we performed DNA microarray analysis (GEO accession number: GSE46922) of T-cells from newly diagnosed children and children with chronic ITP. We found complete separation of the gene expression profiles between the 2 phase  ...[more]

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