Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Comprehensive gene expression profile of human livers from patients with biliary atresia at the time of diagnosis and the corresponding disease and normal controls

ABSTRACT: Liver biopsy samples were obtained from 64 infants with biliary atresia at the time of intraoperative cholangiogram. Liver biopsy samples were obtained from 14 age-matched infants with other causes of intrahepatic cholestasis, and from 7 deceased-donor children. GeneChip® Human Gene 1.0 ST Array (Affymetrix, CA) were used to screen mRNAs whose expression was specifically regulated in the livers from patients with biliary atresia. Gene expression profiling: Liver biopsy samples obtained from infantas with other causes of intrahepatic cholestasis were served as diseased control. Liver tissue obtained from deceased-donor children were served as normal control. A molecular signataure of biliary atresia at the time of diagnosis was identified by comparing hepatic gene expression profile from biliary atresia to those from diseased and normal controls. This dataset is part of the TransQST collection.

ORGANISM(S): Homo sapiens

SUBMITTER: Jorge Bezerra 

PROVIDER: E-GEOD-46960 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Gene expression signature for biliary atresia and a role for interleukin-8 in pathogenesis of experimental disease.

Bessho Kazuhiko K   Mourya Reena R   Shivakumar Pranavkumar P   Walters Stephanie S   Magee John C JC   Rao Marepalli M   Jegga Anil G AG   Bezerra Jorge A JA  

Hepatology (Baltimore, Md.) 20140527 1

<h4>Unlabelled</h4>Biliary atresia (BA) is a progressive fibroinflammatory obstruction of extrahepatic bile ducts that presents as neonatal cholestasis. Due to the overlap in clinical, biochemical, and histological features with other causes of cholestasis, the diagnosis requires an intraoperative cholangiogram. Thus, we determined whether diseased livers express a gene expression signature unique to BA. Applying stringent statistical analysis to a genome-wide liver expression platform of 64 inf  ...[more]

Similar Datasets

Transcriptomics Comprehensive gene expression profile of human livers from patients with biliary atresia at the time of diagnosis and the corresponding disease and normal controls
2013-06-01 | GSE46960 | GEO
Transcriptomics Regulatory T-cell-derived molecular signature predicts two-year outcome in biliary atresia and intrahepatic cholestasis
2022-12-20 | GSE221346 | GEO
Transcriptomics Biliary organoids uncover delayed epithelial development and barrier function in biliary atresia.
2021-10-25 | GSE186444 | GEO
Transcriptomics Human hepatocyte metaplasia in injured humanized mouse livers
2014-09-01 | E-GEOD-58679 | biostudies-arrayexpress
Proteomics Quantitative LC-MS/MS Proteomics of paediatric biliary atresia human liver microsomes
2021-09-09 | PXD020974 | Pride
Proteomics Hepatic Sel1L-Hrd1 ER-associated degradation deficiency leads to intrahepatic cholestasis in mice
2023-03-11 | PXD035243 | Pride
Transcriptomics Gene expression profile of human liver MAIT cells from patients with biliary atresia
2024-05-15 | GSE217466 | GEO
Genomics Pathophysiological role of hepatocyte nuclear factor 6 (HNF6) during cholestatic liver injury
2016-10-06 | GSE80498 | GEO
Genomics Regulatory T-cell-derived molecular signature predicts two-year outcome in biliary atresia and intrahepatic cholestasis
| PRJNA913934 | ENA
Proteomics Quantitative proteomics reveals the protective effects of Huangqi decoction against intrahepatic cholestasis by inhibiting NF-κB/IL-6/STAT3 signaling pathwa
2020-01-13 | PXD014882 | Pride