Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Hang Yin
PROVIDER: E-GEOD-47401 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Price Feodor D FD von Maltzahn Julia J Bentzinger C Florian CF Dumont Nicolas A NA Yin Hang H Chang Natasha C NC Wilson David H DH Frenette Jérôme J Rudnicki Michael A MA
Nature medicine 20140907 10
Diminished regenerative capacity of skeletal muscle occurs during adulthood. We identified a reduction in the intrinsic capacity of mouse adult satellite cells to contribute to muscle regeneration and repopulation of the niche. Gene expression analysis identified higher expression of JAK-STAT signaling targets in 3-week [corrected] 18-month-old mice [corrected]. Knockdown of Jak2 or Stat3 significantly stimulated symmetric satellite stem cell divisions on cultured myofibers. Genetic knockdown of ...[more]