Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Jan Mauer
PROVIDER: E-GEOD-47426 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Mauer Jan J Chaurasia Bhagirath B Goldau Julia J Vogt Merly C MC Ruud Johan J Nguyen Khoa D KD Theurich Sebastian S Hausen A Christine AC Schmitz Joel J Brönneke Hella S HS Estevez Emma E Allen Tamara L TL Mesaros Andrea A Partridge Linda L Febbraio Mark A MA Chawla Ajay A Wunderlich F Thomas FT Brüning Jens C JC
Nature immunology 20140330 5
Obesity and resistance to insulin are closely associated with the development of low-grade inflammation. Interleukin 6 (IL-6) is linked to obesity-associated inflammation; however, its role in this context remains controversial. Here we found that mice with an inactivated gene encoding the IL-6Rα chain of the receptor for IL-6 in myeloid cells (Il6ra(Δmyel) mice) developed exaggerated deterioration of glucose homeostasis during diet-induced obesity, due to enhanced resistance to insulin. Tissues ...[more]