Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Chad Creighton
PROVIDER: E-GEOD-47476 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Zhang Pingyu P Garnett Jeannine J Creighton Chad J CJ Al Sannaa Ghadah Abbas GA Igram Davis R DR Lazar Alexander A Liu Xiuping X Liu Changgong C Pollock Raphael E RE
The Journal of pathology 20140201 3
Malignant peripheral nerve sheath tumours (MPNSTs), which develop sporadically or from neurofibromatosis, recur frequently with high metastatic potential and poor outcome. The polycomb group protein enhancer of zeste homologue 2 (EZH2) is an important regulator for various human malignancies. However, the function of EZH2 in MPNSTs is unknown. Here we report that the EZH2-miR-30d-KPNB1 signalling pathway is critical for MPNST tumour cell survival in vitro and tumourigenicity in vivo. Up-regulate ...[more]