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Global gene expression in the adult Gata6 null mouse pancreas

ABSTRACT: We report the global gene expression of mouse pancreatic cells in a pancreas-specific conditional knock-out mouse for Gata6, as compared with age-matched controls. Total RNA was extracted from the pancreas of 6-8 -week old mice of the two genotypes and analyzed. at this age, Gata6P-/- pancreata are histologically normal, but the acinar differentiation programme is already altered. we observe that loss of Gata6 causes the de-repression of ectopic non-pancreatic genes, as well as some genes involved in the mesenchymal programme. mRNA extracted from the pancreas of 4 controls and 4 Gata6P-/- mice was sequenced.

ORGANISM(S): Mus musculus

SUBMITTER: Enrique Carrillo de Santa Pau

PROVIDER: E-GEOD-47536 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice.

Martinelli Paola P Madriles Francesc F Cañamero Marta M Pau Enrique Carrillo-de Santa EC Pozo Natalia Del ND Guerra Carmen C Real Francisco X FX

Gut 20150116 3

<h4>Background and aims</h4>Gata6 is required to complete and maintain acinar differentiation in the mouse pancreas. Pancreas-specific Gata6 ablation during development causes extensive and persistent acinar-ductal metaplasia, which is considered an initial step of mutant KRas-driven carcinogenesis. Therefore, the Gata6-null pancreas might represent a tumour-prone environment. We investigated whether Gata6 plays a role during pancreatic tumorigenesis.<h4>Design</h4>We analysed genetically engine ...[more]

PMID: 25596178

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