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Ibf1 and Ibf2 are DNA-binding proteins required for insulator function in Drosophila

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Drosophila melanogaster

SUBMITTER: M Lluisa Espinas

PROVIDER: E-GEOD-47559 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Ibf1 and Ibf2 are novel CP190-interacting proteins required for insulator function.

Cuartero Sergi S Fresán Ujué U Reina Oscar O Planet Evarist E Espinàs M Lluisa ML

The EMBO journal 20140206 6

Insulators are DNA-protein complexes that play a central role in chromatin organization and regulation of gene expression. In Drosophila different proteins, dCTCF, Su(Hw), and BEAF bind to specific subsets of insulators most of them having in common CP190. It has been shown that there are a number of CP190-binding sites that are not shared with any other known insulator protein, suggesting that other proteins could cooperate with CP190 to regulate insulator activity. Here we report on the identi ...[more]

PMID: 24502977

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