Differential programming of B cells in Aicda-/- mice [RNA-Seq]
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Marc Hogenbirk
PROVIDER: E-GEOD-47703 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Differential programming of B cells in AID deficient mice.
Hogenbirk Marc A MA Heideman Marinus R MR Velds Arno A van den Berk Paul C M PC Kerkhoven Ron M RM van Steensel Bas B Jacobs Heinz H
PloS one 20130729 7
The Aicda locus encodes the activation induced cytidine deaminase (AID) and is highly expressed in germinal center (GC) B cells to initiate somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin (Ig) genes. Besides these Ig specific activities in B cells, AID has been implicated in active DNA demethylation in non-B cell systems. We here determined a potential role of AID as an epigenetic eraser and transcriptional regulator in B cells. RNA-Seq on different B cell subs ...[more]
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