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Uniform response to aneuploidy in human cells

ABSTRACT: There are many different types and origins of aneuploidy, but whether there is a uniform cellular response to aneuploidy in human cells has not been addressed so far. To uncover a uniform transcriptional response to aneuploidy we evaluted the transcription profiles of trisomic and tetrasomic cell lines and cell lines with complex aneuploid karyotypes. mRNA expression analysis of aneuploid cell lines derived from HCT116 compared to the HCT116 diploid cell line. With the exception of HCT116 3/3, three biological replicates of the Microarray experiment were performed.

ORGANISM(S): Homo sapiens

SUBMITTER: Milena DÃ¼rrbaum

PROVIDER: E-GEOD-47830 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Unique features of the transcriptional response to model aneuploidy in human cells.

Dürrbaum Milena M Kuznetsova Anastasia Yurievna AY Passerini Verena V Stingele Silvia S Stoehr Gabriele G Storchová Zuzana Z

BMC genomics 20140218

<h4>Background</h4>Aneuploidy, a karyotype deviating from multiples of a haploid chromosome set, affects the physiology of eukaryotes. In humans, aneuploidy is linked to pathological defects such as developmental abnormalities, mental retardation or cancer, but the underlying mechanisms remain elusive. There are many different types and origins of aneuploidy, but whether there is a uniform cellular response to aneuploidy in human cells has not been addressed so far.<h4>Results</h4>Here we evalua ...[more]

PMID: 24548329

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