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The transcription factor GATA3 is critical for the development of all IL-7Ra-expressing innate lymphoid cells (ILCs) and maintenance of type 2 ILCs

ABSTRACT: Innate lymphoid cells (ILCs) play critical roles during innate immune responses to pathogens and lymphoid organ development. IL-7Ra+ ILC subsets, similar to T helper (Th) cell subsets, produce distinctive effector cytokines. The molecular control of IL-7Ra+ ILC development and maintenance has yet to be dissected. Here we report that GATA3 is indispensable for the development of all IL-7Ra+ ILC subsets and T cells. Gata3 conditional deficient mice have no lymph nodes and are susceptible to Citrobactor rodentium infection. Genome-wide gene analyses indicate that GATA3 regulates similar set of cytokines and receptors in ILC2s and Th2 cells and is critical for the maintenance of ILC2s. Thus, GATA3 plays parallel roles in establishing and regulating both adaptive and innate lymphocytes. To identify GATA3 regulated genes in type 2 innate lymphoid cells by tamoxifen-mediated acute deletion of Gata3 gene.

ORGANISM(S): Mus musculus

SUBMITTER: Gangqing Hu 

PROVIDER: E-GEOD-47851 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The transcription factor GATA3 is critical for the development of all IL-7Rα-expressing innate lymphoid cells.

Yagi Ryoji R   Zhong Chao C   Northrup Daniel L DL   Yu Fang F   Bouladoux Nicolas N   Spencer Sean S   Hu Gangqing G   Barron Luke L   Sharma Suveena S   Nakayama Toshinori T   Belkaid Yasmine Y   Zhao Keji K   Zhu Jinfang J  

Immunity 20140313 3

Innate lymphoid cells (ILCs) are critical in innate immune responses to pathogens and lymphoid organ development. Similar to CD4(+) T helper (Th) cell subsets, ILC subsets positive for interleukin-7 receptor α (IL-7Rα) produce distinct sets of effector cytokines. However, the molecular control of IL-7Rα(+) ILC development and maintenance is unclear. Here, we report that GATA3 was indispensable for the development of all IL-7Rα(+) ILC subsets and T cells but was not required for the development o  ...[more]

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