Transcription profiling of cochleae from young and middle aged mice subjected to calorie restriction to examine age-related changes and calorie restriction-induced changes in gene expression in the cochlea.
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Shinichi Someya
PROVIDER: E-GEOD-4786 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Caloric restriction suppresses apoptotic cell death in the mammalian cochlea and leads to prevention of presbycusis.
Someya Shinichi S Yamasoba Tatsuya T Weindruch Richard R Prolla Tomas A TA Tanokura Masaru M
Neurobiology of aging 20060804 10
Presbycusis is characterized by an age-related progressive decline of auditory function, and arises mainly from the degeneration of hair cells or spiral ganglion (SG) cells in the cochlea. Here we show that caloric restriction suppresses apoptotic cell death in the mouse cochlea and prevents late onset of presbycusis. Calorie restricted (CR) mice, which maintained body weight at the same level as that of young control (YC) mice, retained normal hearing and showed no cochlear degeneration. CR mic ...[more]
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2012-02-04 | E-GEOD-34773 | biostudies-arrayexpress
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2008-12-30 | E-GEOD-11244 | biostudies-arrayexpress
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2015-05-08 | E-GEOD-68646 | biostudies-arrayexpress
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