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The Cellular and Genomic Response of Dopaminergic Neurons (N27) to Commericial “Capped” Nanosilver

ABSTRACT: Global gene expression indicated that N27 neurons exposed to each nanoAg material (1.0 ppm, 18 hr) responded primarily to PVP coated nanoAg of both sizes with affected pathways largely associated with mitochondrial dysfunction (PVP 75 nm nanoAg) and Nrf-2 mediated oxidative stress (PVP 10 nm nanoAg) pathways. N27 rat dopaminergic neurons were exposed to non-cytoxic (0.5-5.0 ppm) concentrations of nanoAg of different sizes (10 nm, 75 nm) and “cappings” (PVP, citrate).

ORGANISM(S): Rattus norvegicus

SUBMITTER: William Ward

PROVIDER: E-GEOD-48087 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The Cellular and Genomic Response of Dopaminergic Neurons (N27) to Commericial “Capped” Nanosilver

Project description:Global gene expression indicated that N27 neurons exposed to each nanoAg material (1.0 ppm, 18 hr) responded primarily to PVP coated nanoAg of both sizes with affected pathways largely associated with mitochondrial dysfunction (PVP 75 nm nanoAg) and Nrf-2 mediated oxidative stress (PVP 10 nm nanoAg) pathways.

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