Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Meiyun Fan
PROVIDER: E-GEOD-48160 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Fan Meiyun M Krutilina Raisa R Sun Jing J Sethuraman Aarti A Yang Chuan He CH Wu Zhao-Hui ZH Yue Junming J Pfeffer Lawrence M LM
The Journal of biological chemistry 20130806 38
MicroRNAs (miRNAs) regulate mRNA stability and translation through the action of the RNAi-induced silencing complex. In this study, we systematically identified endogenous miRNA target genes by using AGO2 immunoprecipitation (AGO2-IP) and microarray analyses in two breast cancer cell lines, MCF7 and MDA-MB-231, representing luminal and basal-like breast cancer, respectively. The expression levels of ∼70% of the AGO2-IP mRNAs were increased by DROSHA or DICER1 knockdown. In addition, integrated a ...[more]