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TFAM ChIP-seq in HeLa cells

ABSTRACT: ChIP-seq data characterizing the occupancy of TFAM over the mitochondrial and nuclear genomes in HeLa cells. Characterization of mitochondrial and nuclear genome-wide TFAM binding in HeLa cells

ORGANISM(S): Homo sapiens

SUBMITTER: Georgi Mairnov

PROVIDER: E-GEOD-48176 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genome-wide analysis reveals coating of the mitochondrial genome by TFAM.

Wang Yun E YE Marinov Georgi K GK Wold Barbara J BJ Chan David C DC

PloS one 20130826 8

Mitochondria contain a 16.6 kb circular genome encoding 13 proteins as well as mitochondrial tRNAs and rRNAs. Copies of the genome are organized into nucleoids containing both DNA and proteins, including the machinery required for mtDNA replication and transcription. The transcription factor TFAM is critical for initiation of transcription and replication of the genome, and is also thought to perform a packaging function. Although specific binding sites required for initiation of transcription h ...[more]

PMID: 23991223

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TFAM deficiency promotes mitochondrial dysfunction to drive inflammation in the corneas of dry eye disease through mtDNA stress-mediated AIM2 inflammasome activation

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