Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Georgi Mairnov
PROVIDER: E-GEOD-48176 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Wang Yun E YE Marinov Georgi K GK Wold Barbara J BJ Chan David C DC
PloS one 20130826 8
Mitochondria contain a 16.6 kb circular genome encoding 13 proteins as well as mitochondrial tRNAs and rRNAs. Copies of the genome are organized into nucleoids containing both DNA and proteins, including the machinery required for mtDNA replication and transcription. The transcription factor TFAM is critical for initiation of transcription and replication of the genome, and is also thought to perform a packaging function. Although specific binding sites required for initiation of transcription h ...[more]